Fig. 5.

Exemplary RIfS experiments illustrating the different behavior of ${\mathrm{R}}_{\mathrm{Side}}$ and R-oligopeptides. Change in bulk concentration is indicated by blue dashed lines. a ${\mathrm{R}}_{\mathrm{Side}}$ added to a POPC:POPG 1:1 membrane, the membrane was dissolved at the second addition of peptide as the membrane thickness decreases; (b/c) step-wise increase in ${\mathrm{R}}_8$-concentration in the presence of a POPC:POPG 1:1 bilayer (b) and POPC (c). No significant increase in optical thickness and hence no binding is observed in the absence of negative charges on the bilayer