Figure 2.

The immune system of the skin reveals a diverse population in effector immunocytes. The epidermis can be divided into four layers, from superficial to deep: stratum corneum, stratum granulosum, stratum spinosum and stratum basale. In the epidermis, Langerhans cells partake in antigen presentation and migration to lymph nodes. γδ T cells, also known as dendritic epidermal T cells (DETCs), are key cytokine producing cells in mice skin. Cytotoxic CD8+ T cells can be found in the deep epidermis. Within the dermis resides many specialized immune cell populations, including dermal dendritic cells, CD4+ T cell subsets (e.g. Th1, Th2, Th17 and T follicular helper) and B cells. Additionally, mast cells and macrophages are present.