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. 2021 Apr 12;12:660203. doi: 10.3389/fimmu.2021.660203

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Copyright © 2021 Lowy, Makker and Moalem-Taylor

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Reported and speculative neuroimmune interactions within the skin in PHN and HIV-induced neuropathy. In PHN, anterograde transport of VSV results in dysregulation of cutaneous neuropeptide (CGRP, SP, VIP) signalling, increasing susceptibility to various pathologies. Altered ncRNA balance may modulate neuronal and immune function. HIV-induced neuropathy is associated with infiltrating neurotoxic macrophages and T cells. NRTI treatment drives abnormal cannabinoid system signalling, a system implicated in the pathogenesis of neuropathic pain.