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. 2021 Apr 12;12:651191. doi: 10.3389/fimmu.2021.651191

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Copyright © 2021 Wang, Wang, Banerjee, Liang, Du, Boor, Hoffman and Khan

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Spontaneous development of SLE- and AIH-like diseases in MRL/lpr mice. Serum ANA levels (A) and serum ASMA levels (B) in C57BL/6 (C57), MRL+/+ and MRL/lpr mice. Histopathology of liver (C) shows marked various peri-portal infiltrates (arrows) in MRL/lpr mice. Renal histopathology (lower panel) shows glomerulus with hypercellularity and red blood cells in Bowman’s spod and adjacent tubule (arrows) in MRL/lpr mice, indicative of acute glomerulonephritis (H&E). n = 5, **p < 0.01.