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. 2021 Apr 12;12:651191. doi: 10.3389/fimmu.2021.651191

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Copyright © 2021 Wang, Wang, Banerjee, Liang, Du, Boor, Hoffman and Khan

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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SLE-associated gut microbiome diversity and composition. Fecal pellets from C57BL/6 (C), MRL+/+ (MRL) and MRL/lpr (Lpr) mice were collected and bacterial DNA was isolated and subjected to 16s rDNA sequencing to evaluate the composition of microbiome in each mice. (A) The variety of organisms in a community, termed as alpha diversity. (B) Different mouse strains showed distinct microbiome pattern at 6 week and 18 weeks of age. (C) Age-associated differences in fecal microbiome from MRL+/+ and MRL/lpr mice at phylum level. (D) F/B ratio in MRL+/+ and MRL/lpr mice. (E) Taxa relative abundance at family level in MRL+/+ and MRL/lpr mice. (F) Taxa relative abundance at genus level in MRL+/+ and MRL/lpr mice. Results are mean ± SEM. n = 4 *p < 0.05; ^# p < 0.1.