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. 2021 Apr 12;12:651191. doi: 10.3389/fimmu.2021.651191

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Copyright © 2021 Wang, Wang, Banerjee, Liang, Du, Boor, Hoffman and Khan

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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NAC treatment attenuated the auto-inflammatory responses in MRL/lpr mice. Serum ANA (A) and anti-dsDNA (B) levels in the control and NAC-treated mice. (C) Diminution of hepatic lymphocytes following NAC treatment. (D) Serum cytokines, measured using a multiplex assay in the control and NAC-treated mice. (E) RT-PCR for markers of inflammasome activation, cytokines, redox-related enzymes and chemokines in the control and NAC-treated mice. Results are mean ± SEM. n = 5 *p < 0.05; **p < 0.01, ^# p < 0.1.