Table 1.
Clinical and pathological characteristics of the analyzed chondrosarcoma tumors.
| Grade 1. (Sample # = 17) | Grade 2. (Sample # = 30) | Grade 3. (Sample # = 5) | Dedifferentiated (Sample # = 24) | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Mean ± SD | range | Mean ± SD | range | Mean ± SD | range | Mean ± SD | range | ||||
| Age, years (n=17) | 49 ± 14 | 18-69 | Age, years (#=30) | 57 ± 16 | 33-83 | Age, years (#=5) | 56 ± 13 | 39-73 | Age, years (#=24) | 59 ± 13 | 39-82 |
| Sex | # | % | Sex | # | % | Sex | # | % | Sex | # | % |
| male | 6 | 35 | male | 15 | 50 | male | 3 | 60 | male | 15 | 63 |
| female | 11 | 65 | female | 15 | 50 | female | 2 | 40 | female | 9 | 38 |
| Mean ± SD | range | Mean ± SD | range | Mean ± SD | range | Mean ± SD | range | ||||
| Tumor Size, cm3 (n=14) | 137 ± 235 | 1.2-900 | Tumor Size, cm3 (n=25) | 705 ± 1253 | 1.8-5888 | Tumor Size, cm3 (n=5) | 463 ± 499 | 36-1248 | Tumor Size, cm3 (n=21) | 591 ± 875 | 12-3680 |
| Anatomic Site | # | % | Anatomic Site | # | % | Anatomic Site | # | % | Anatomic Site | # | % |
| Spine | 2 | 12 | Spine | 0 | 0 | Spine | 1 | 20 | Spine | 1 | 4.2 |
| Scapula/clavicle | 3 | 18 | Scapula/clavicle | 3 | 10 | Scapula/clavicle | 0 | 0 | Scapula/clavicle | 2 | 8.3 |
| Sternum | 1 | 5.9 | Sternum | 0 | 0 | Sternum | 0 | 0 | Sternum | 0 | 0 |
| Rib(s) | 0 | 0 | Rib(s) | 2 | 6.7 | Rib(s) | 0 | 0 | Rib(s) | 1 | 4.2 |
| Humerus | 1 | 5.9 | Humerus | 5 | 17 | Humerus | 0 | 0 | Humerus | 2 | 8.3 |
| Pelvis | 1 | 5.9 | Pelvis | 5 | 17 | Pelvis | 3 | 60 | Pelvis | 5 | 21 |
| Sacrum | 2 | 12 | Sacrum | 2 | 6.7 | Sacrum | 0 | 0 | Sacrum | 0 | 0 |
| Femur | 5 | 29 | Femur | 10 | 33 | Femur | 1 | 20 | Femur | 12 | 50 |
| Tibia | 0 | 0 | Tibia | 2 | 6.7 | Tibia | 0 | 0 | Tibia | 1 | 4.2 |
| Fibula | 2 | 12 | Fibula | 1 | 3.3 | Fibula | 0 | 0 | Fibula | 0 | 0 |
| Margin, mm | # | % | Margin, mm | # | % | Margin, mm | # | % | Margin, mm | # | % |
| 0 | 3 | 18 | 0 | 4 | 13 | 0 | 2 | 40 | 0 | 8 | 33 |
| <1 | 3 | 18 | <1 | 6 | 20 | <1 | 2 | 40 | <1 | 5 | 21 |
| ≥1 | 8 | 47 | ≥1 | 19 | 63 | ≥1 | 1 | 20 | ≥1 | 10 | 42 |
| unknown | 3 | 18 | unknown | 1 | 3.3 | unknown | 0 | 0 | unknown | 1 | 4.2 |
| Extra-osseous extension | # | % | Extra-osseous extension | # | % | Extra-osseous extension | # | % | Extra-osseous extension | # | % |
| yes | 9 | 53 | yes | 24 | 80 | yes | 5 | 100 | yes | 22 | 92 |
| no | 6 | 35 | no | 6 | 20 | no | 0 | 0 | no | 1 | 4.2 |
| unknown | 2 | 12 | unknown | 0 | 0 | unknown | 0 | 0 | unknown | 1 | 4.2 |
| Metastasis at presentation | # | % | Metastasis at presentation | # | % | Metastasis at presentation | # | % | Metastasis at presentation | # | % |
| yes | 0 | 0 | yes | 0 | 0 | yes | 0 | 0 | yes | 7 | 29 |
| no | 17 | 100 | no | 30 | 100 | no | 5 | 100 | no | 17 | 71 |
| Metastasis | # | % | Metastasis | # | % | Metastasis | # | % | Metastasis | # | % |
| yes | 0 | 0 | yes | 6 | 20 | yes | 2 | 40 | yes | 22 | 92 |
| no | 17 | 100 | no | 24 | 80 | no | 3 | 60 | no | 2 | 8.3 |
| Local recurrence | # | % | Local recurrence | # | % | Local recurrence | # | % | Local recurrence | # | % |
| yes | 2 | 12 | yes | 7 | 23 | yes | 1 | 20 | yes | 7 | 29 |
| no | 15 | 88 | no | 23 | 77 | no | 4 | 80 | no | 17 | 71 |
| Chemotherapy given | n | % | Chemotherapy given | n | % | Chemotherapy given | n | % | Chemotherapy given | n | % |
| yes | 0 | 0 | yes | 4 | 13 | yes | 2 | 40 | yes | 16 | 67 |
| no | 17 | 100 | no | 26 | 87 | no | 3 | 60 | no | 8 | 33 |
| Radiotherapy, pre-surgery | n | % | Radiotherapy, pre-surgery | n | % | Radiotherapy, pre-surgery | n | % | Radiotherapy, pre-surgery | n | % |
| yes | 2 | 12 | yes | 6 | 20 | yes | 2 | 40 | yes | 21 | 88 |
| no | 15 | 88 | no | 24 | 80 | no | 3 | 60 | no | 3 | 13 |
| Radiotherapy, post-surgery | n | % | Radiotherapy, post-surgery | n | % | Radiotherapy, post-surgery | n | % | Radiotherapy, post-surgery | n | % |
| yes | 5 | 29 | yes | 7 | 23 | yes | 3 | 60 | yes | 10 | 42 |
| no | 12 | 71 | no | 23 | 77 | no | 2 | 20 | no | 14 | 58 |