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. 2021 Apr 12;11:592107. doi: 10.3389/fonc.2021.592107

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Copyright © 2021 Han, Yang, Wang, Zeng and Tian.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Differential patterns of expressional and clinical features of patients with TCGA HNSCC in cluster 1–4 subgroups. (A) Consensus clustering cumulative distribution function (CDF) and (B) relative change in the area under the CDF curve from k = 2 to k = 9. (C) Consensus clustering matrix was assessed by k = 4. (D) The tracking plot of the HNSCC samples. (E) The survival analysis for the four clusters by the Kaplan–Meier method. (F) The clinicopathological characteristics of the four clusters were determined by coexpression patterns of the consensus expression of 13 selected m⁵C-related regulators (*p < 0.05; **p < 0.01; ***p < 0.001).