Figure 7.

The profiling of differentially expressed genes (DEGs) and their functional annotations from the two risk subgroups. (A) The volcano plot shows the DEGs in the two subgroups. The top 10 upregulated and downregulated genes with the highest |log₂FC| value are labeled with blue dots. Significantly enriched the Reactome pathway analysis of (B) 359 upregulated genes and (C) 366 downregulated genes was visualized using the package GOplot in R. The plot includes eight Reactome pathway terms. The genes with at least two terms and the terms that included at least eight genes are demonstrated in this plot. log₂FC represents the difference between the high- and low-risk subgroups. The bubble chart shows the top 10 significant enrichment terms of (D) 359 upregulated genes and (E) 366 downregulated genes in the Reactome database.