TABLE 1.
Common targets between PL and HCC.
| Gene name | Gene symbol | Uniprot ID |
|---|---|---|
| Histone acetyltransferase p300 | EP300 | Q09472 |
| Indoleamine 2,3-dioxygenase | IDO1 | P14902 |
| Dual specificity phosphatase Cdc25B | CDC25B | P30305 |
| Serine/threonine-protein kinase PIM1 | PIM1 | P11309 |
| Dual specificity protein phosphatase 1 | DUSP1 | P28562 |
| Monoamine oxidase B | MAOB | P27338 |
| Glutathione reductase | GSR | P00390 |
| Serine/threonine-protein kinase/endoribonuclease IRE1 | ERN1 | O75460 |
| Myoglobin | MB | P02144 |
| C-X-C chemokine receptor type 4 | CXCR4 | P61073 |
| RAC-alpha serine/threonine-protein | AKT1 | P31749 |
| Mitogen-activated protein kinase 8 | MAPK8 | P45983 |
| Superoxide dismutase [Cu-Zn] | SOD1 | P00441 |
| Transcription factor NF-E2 | NFE2 | Q16621 |
| Solute carrier family 2 | SLC2A4 | P14672 |
| Proto-oncogene tyrosine-protein kinase | SRC | P12931 |
| Cyclin-dependent kinase inhibitor 1 | CDKN1A | P38936 |
| DNA topoisomerase I | TOP1 | P11387 |
| RAF proto-oncogene serine/threonine-protein kinase | RAF1 | P04049 |
| Tumor suppressor p53/oncoprotein Mdm2 | TP53 | P04637 |
| Vitamin D receptor | VDR | P11473 |
| 15-Hydroxyprostaglandin dehydrogenase [NAD+] | HPGD | P15428 |
| 78 kDa glucose-regulated protein | HSPA5 | P11021 |
| Aldehyde dehydrogenase 1A1 | ALDH1A1 | P00352 |
| Arachidonate 15-lipoxygenase | ALOX15 | P16050 |
| ATP-dependent DNA helicase Q1 | RECQL | P46063 |
| Caspase-1 | CASP1 | P29466 |
| Caspase-7 | CASP7 | P55210 |
| DNA polymerase kappa | POLK | Q9UBT6 |
| Dual specificity mitogen-activated protein kinase kinase | MAP2K1 | Q02750 |
| Endoplasmic reticulum-associated amyloid beta-peptide-binding protein | HSD17B10 | Q99714 |
| Microtubule-associated protein tau | MAPT | P10636 |
| Mitogen-activated protein kinase kinase kinase 14 | MAP3K14 | Q99558 |
| Mitogen-activated protein kinase; ERK1/ERK2 | MAPK1 | P28482 |
| Nuclear factor NF-kappa-B p65 subunit | RELA | Q04206 |
| Transcription factor AP-1 | JUN | P05412 |
| Transcription factor jun-D | JUND | P17535 |
| Estrogen receptor, ER | ESR1 | P03372 |
| Dual specificity mitogen-activated protein kinase kinase 4 | MAP2K4 | P45985 |
| Signal transducer and activator of transcription 3 | STAT3 | P40763 |
| Tyrosine-protein phosphatase non-receptor type 1 | PTPN1 | P18031 |
| E3 ubiquitin-protein ligase CBL | CBL | P22681 |
| Nuclear receptor subfamily 0 group B member 2 | NR0B2 | Q15466 |
| E3 ubiquitin-protein ligase Mdm2 | MDM2 | Q00987 |
| Serine/threonine-protein kinase mTOR | MTOR | P42345 |
| Heat shock protein HSP 90-alpha | HSP90AA1 | P07900 |
| Cyclin-dependent kinase 2 | CDK2 | P24941 |
| S-phase kinase-associated protein 2 | SKP2 | Q13309 |
| E3 ubiquitin-protein ligase CCNB1IP1 | CCNB1 | Q9NPC3 |
| G1/S-specific cyclin-E1 | CCNE1 | P24864 |
| G1/S-specific cyclin-D3 | CCND3 | P30281 |
| Cyclin-dependent kinase 4 | CDK4 | P11802 |
| Glycogen synthase kinase-3 beta | GSK3B | P49841 |
| Cyclic AMP-dependent transcription factor ATF-2 | ATF2 | P15336 |
| Integrin-linked protein kinase | ILK | Q13418 |
| Rapamycin-insensitive companion of mTOR | RICTOR | Q6R327 |
| Nitric oxide synthase, endothelial | NOS3 | P29474 |
| Zinc finger protein Gfi-1 | CDKNIA | Q99684 |
| PCNA-associated factor | PCNA | Q15004 |
| Forkhead box protein O3 | FOXO3 | O43524 |
| Forkhead box protein O1 | FOXO1 | Q12778 |
| Breast cancer anti-estrogen resistance protein 1 | BCAR1 | P56945 |
| Baculoviral IAP repeat-containing protein 3 | BIRC3 | Q13489 |
| Interleukin-6 | IL6 | P05231 |
| Phosphatidylinositol 3-kinase regulatory subunit alpha | PIK3R1 | P27986 |
| Bcl2-associated agonist of cell death | BAD | Q92934 |
| Histone-lysine N-methyltransferase 2A | KMT2A | Q03164 |
| Interleukin-4 | IL4 | P05112 |
| Early activation antigen CD69 | CD69 | Q07108 |
| M-phase inducer phosphatase 1 | CDC25A | P30304 |
| CASP8 and FADD-like apoptosis regulator | CFLAR | O15519 |
| Matrix metalloproteinase-9 | MMP9 | P14780 |
| Prostaglandin G/H synthase 2 | PTGS2 | P35354 |
| DNA-(apurinic or apyrimidinic site) lyase | APEX1 | P27695 |
| Perilipin-1 | PLIN1 | O60240 |
| Muscleblind-like protein 3 | MBNL3 | Q9NUK0 |
| Interleukin-2 | IL2 | P60568 |
| Interleukin-2 receptor subunit alpha | IL2RA | P01589 |
| Cytochrome P450 1A2 | CYP1A2 | P05177 |
| Ubiquinol oxidase 1a | AOX1 | Q39219 |
| Cytochrome P450 3A4 | CYP3A4 | P08684 |
| Cytochrome P450 2C9 | CYP2C9 | P11712 |
| Cytochrome P450 2D6 | CYP2D6 | P10635 |
| Interferon gamma | IFNG | P01579 |
| NAD(P)H dehydrogenase [quinone] 1 | NQO1 | P15559 |