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. 2021 Apr 12;12:643609. doi: 10.3389/fpsyt.2021.643609

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Copyright © 2021 Roughan, Campos, García-Marín, Cuéllar-Partida, Lupton, Hickie, Medland, Wray, Byrne, Ngo, Martin and Rentería.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of chronic pain on antidepressant benefits in AGDS cohort. Forest plots depicting the results from: (A) association of chronic pain with self-reported benefits from general antidepressant treatment; and associations between antidepressant treatment response and (B) self-reported chronic pain or (C) self-reported prescription for chronic pain, while adjusting for the effects of sex and age at commencement of taking the antidepressant (*p < 0.05; **p < 0.005 statistical significance after Bonferroni correction for multiple testing; AGDS data only). Further details are in Supplementary Figure 4 and Supplementary Tables 4, 5.