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. 2021 Feb 25;16(4):681–693. doi: 10.1016/j.stemcr.2021.01.019

Table 1.

Adult Neurogenesis in Mouse Models of AD

Mouse model Mutation(s) Plaque formation Tangle formation Neurogenesis Neurogenic region Age Markers Reference
3xTg APPswe KM670/671NL, PS-1 M146V, MAPT P301L 6 months 6 months ↓ DG By 4 months ↓ HH3 (Rodriguez et al., 2008)
↓ DG At 11 & 18 months ↓ BrdU, Ki67, DCX (Hamilton et al., 2010)
↓ DG, SVZ 2 months ↓ Ki67, DCX, Ki67/DCX, Ki67/GFAP (Hamilton et al., 2015)
↓ DG 6 months ↓ BrdU/NeuN, DCX (Valero et al., 2014)
5xFAD APPswe KM670/671NL, APPfl I716V, APPlon V717L, PS-1 M146L, PS-1 L286V 2–3 months N/A ↓ DG By 2 months ↓ DCX (Moon et al., 2014)
↓ DG 2 months ↓ DCX
No Δ Ki67		 (Zaletel et al., 2018)
Tg2576, APPswe APPswe KM670/671NL 9–13 months N/A ↓ SVZ 11–12 months ↓ BrdU, GFAP, NeuN (Haughey et al., 2002)
↓ SVZ 1.5 months ↓ BrdU, GFAP, Sox2, BrdU/calretinin, BrdU/NeuN
↑ DCX		 (Scopa et al., 2019)
PDAPP, APPind APPind V717F 6 months N/A ↓ DG (SGZ) 12 months ↓ BrdU, DCX (Donovan et al., 2006)
↑ DG (GCL) 12 months ↑ BrdU, BrdU/DCX
J20, PDGF APPswe/ind APPswe KM670/671NL, APPind V717F 5–7 months N/A ↑ DG, SVZ SVZ 3 months
DG 1 year		 ↑ BrdU, DCX (Jin et al., 2004a)
↑ DG 3 months ↑ BrdU, Ki67, NeuN, PSA-NCAM (Lopez-Toledano and Shelanski, 2007)
↓ DG 5 months ↓ BrdU
↓ DG 2-3 months ↓ GFP reporter, morphology (Sun et al., 2009)
Ps-1 knockin PS-1 M146V No data N/A ↓ DG 3 months ↓ BrdU, BrdU/NeuN (Wang et al., 2004)
PS-1 PS-1 P117L NA N/A ↓ DG By 3 months ↓ BrdU, βIII-tubulin, calbindin (Wen et al., 2004)
PS-1 PS-1 A246E NA N/A ↑ DG 12 weeks ↑ BrdU
No Δ BrdU/NeuN		 (Chevallier et al., 2005)
APP/PS-1 APPswe KM670/671NL, PS-1-dE9 6 months N/A ↓ DG, SVZ 6 months ↓ BrdU, BrdU/Neun
No Δ Ki67		 (Verret et al., 2007)
↓ DG, SVZ 2 months ↓ BrdU, BrdU/DCX (Demars et al., 2010)
APP/PS-1, Nestin-GFP APPswe KM670/671NL, PS-1-dE9 6 months N/A ↓ DG by 3 months BrdU, DCX, GFAP, Nestin (Zeng et al., 2016)