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. 2021 Mar 11;16(4):913–925. doi: 10.1016/j.stemcr.2021.02.011

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© 2021 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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Thyroid Tumor Markers and Subcutaneous Transplantation of (Irradiated) Murine Thyroid Cells

(A) Boxplots with log2-expression values of tumor-specific upregulated gene behavior in primary thyroid tissues (red, n = 5 independent donor biopsies) to the early (passage 0–2; green, n = 9 independent donor biopsies) and later (passage 3–4; blue, n = 9 independent donor biopsies) passage organoids. See Table S3 for p values, with the use of two-sided Mann-Whitney test.

(B) Boxplots with log2-expression values of tumor-specific downregulated gene behavior in primary thyroid tissues (red, n = 5 independent donor biopsies) to the early (passage 0–2; green, n = 9 independent donor biopsies) and later (passage 3–4; blue, n = 9 independent donor biopsies) passage organoids. See Table S3 for p values, with the use of two-sided Mann-Whitney test.

(C) Schematic representation of a subcutaneous in vivo mouse model to test the ability of non-irradiated and irradiated organoids to form tumor-like tissue.

See also Table S3.