Table 3.

NODDI metrics including NDI, ODI, and Viso in white matter for ROI analysis between acromegaly and controls.

Tracts	NDI, Mean ± SD			ODI, Mean ± SD			Viso, Mean ± SD
	Acromegaly	Controls	P	Acromegaly	Controls	P	Acromegaly	Controls	P
ar_l	0.57 ± 0.03	0.59 ± 0.02	.01	0.24 ± 0.01	0.24 ± 0.01	.35	0.09 ± 0.02	0.09 ± 0.02	.80
ar_r	0.57 ± 0.03	0.59 ± 0.03	.06	0.24 ± 0.01	0.24 ± 0.01	.15	0.09 ± 0.02	0.09 ± 0.02	.72
atr_l	0.60 ± 0.05	0.63 ± 0.02	.00	0.22 ± 0.01	0.22 ± 0.01	.45	0.09 ± 0.01	0.09 ± 0.01	.43
atr_r	0.59 ± 0.04	0.62 ± 0.03	.00	0.22 ± 0.01	0.22 ± 0.01	.89	0.08 ± 0.01	0.08 ± 0.01	.32
cgc_l	0.62 ± 0.04	0.64 ± 0.03	.03	0.14 ± 0.02	0.14 ± 0.02	.93	0.08 ± 0.01	0.08 ± 0.01	.96
cgc_r	0.59 ± 0.04	0.62 ± 0.03	.01	0.16 ± 0.02	0.16 ± 0.02	.55	0.08 ± 0.02	0.07 ± 0.01	.01
cgh_l	0.52 ± 0.05	0.53 ± 0.04	.48	0.26 ± 0.02	0.27 ± 0.02	.23	0.12 ± 0.04	0.13 ± 0.03	.55
cgh_r	0.51 ± 0.05	0.53 ± 0.03	.16	0.26 ± 0.03	0.26 ± 0.02	.77	0.12 ± 0.04	0.13 ± 0.04	.75
cst_l	0.68 ± 0.03	0.69 ± 0.02	.09	0.16 ± 0.01	0.17 ± 0.01	.35	0.11 ± 0.01	0.11 ± 0.01	.11
cst_r	0.68 ± 0.03	0.69 ± 0.02	.02	0.16 ± 0.01	0.16 ± 0.01	.08	0.11 ± 0.01	0.11 ± 0.01	.79
fma	0.60 ± 0.03	0.62 ± 0.02	.09	0.12 ± 0.01	0.13 ± 0.01	.02	0.13 ± 0.02	0.12 ± 0.02	.14
fmi	0.58 ± 0.04	0.63 ± 0.03	.00	0.16 ± 0.01	0.17 ± 0.01	.00	0.10 ± 0.01	0.11 ± 0.02	.11
ifo_l	0.55 ± 0.04	0.57 ± 0.02	.01	0.16 ± 0.01	0.17 ± 0.01	.01	0.09 ± 0.01	0.09 ± 0.01	.13
ifo_r	0.55 ± 0.04	0.58 ± 0.03	.00	0.16 ± 0.01	0.17 ± 0.01	.02	0.09 ± 0.01	0.09 ± 0.01	.88
ilf_l	0.52 ± 0.04	0.54 ± 0.03	.07	0.16 ± 0.01	0.17 ± 0.01	.00	0.08 ± 0.01	0.07 ± 0.01	.04
ilf_r	0.52 ± 0.04	0.54 ± 0.03	.05	0.15 ± 0.01	0.16 ± 0.01	.00	0.08 ± 0.01	0.08 ± 0.01	.48
mcp	0.78 ± 0.04	0.80 ± 0.03	.04	0.20 ± 0.03	0.20 ± 0.02	.72	0.21 ± 0.04	0.19 ± 0.04	.03
ml_l	0.66 ± 0.04	0.67 ± 0.03	.60	0.20 ± 0.01	0.20 ± 0.01	.12	0.15 ± 0.02	0.17 ± 0.02	.06
ml_r	0.66 ± 0.05	0.67 ± 0.03	.56	0.20 ± 0.02	0.20 ± 0.01	.13	0.16 ± 0.02	0.17 ± 0.02	.20
ptr_l	0.53 ± 0.04	0.54 ± 0.02	.31	0.18 ± 0.01	0.19 ± 0.01	.00	0.08 ± 0.02	0.08 ± 0.01	.08
ptr_r	0.54 ± 0.04	0.55 ± 0.03	.21	0.18 ± 0.01	0.18 ± 0.01	.02	0.09 ± 0.01	0.09 ± 0.01	.28
slf_l	0.64 ± 0.04	0.66 ± 0.03	.03	0.17 ± 0.01	0.17 ± 0.01	.04	0.09 ± 0.01	0.08 ± 0.01	.02
slf_r	0.62 ± 0.04	0.65 ± 0.03	.00	0.18 ± 0.02	0.18 ± 0.02	.83	0.08 ± 0.01	0.08 ± 0.01	.64
str_l	0.65 ± 0.04	0.66 ± 0.03	.21	0.20 ± 0.01	0.21 ± 0.01	.16	0.09 ± 0.01	0.08 ± 0.01	.06
str_r	0.64 ± 0.03	0.66 ± 0.02	.03	0.20 ± 0.01	0.21 ± 0.01	.04	0.09 ± 0.01	0.08 ± 0.01	.03
unc_l	0.51 ± 0.04	0.54 ± 0.03	.00	0.20 ± 0.02	0.21 ± 0.02	.01	0.07 ± 0.02	0.07 ± 0.01	.64
unc_r	0.50 ± 0.04	0.53 ± 0.03	.00	0.20 ± 0.01	0.20 ± 0.01	.27	0.06 ± 0.01	0.06 ± 0.01	.63

l, left; r, right; ar, acoustic radiation; atr, anterior thalamic radiation; cgc, cingulate gyrus part of cingulum; cgh, parahippocampal part of cingulum; cst, corticospinal tract; fma, forceps major; fmi, forceps minor; ifo, inferior fronto-occipital fasciculus; ilf, inferior longitudinal fasciculus; mcp, middle cerebellar peduncle; ml, medial lemniscus; ptr, posterior thalamic radiation; slf, superior longitudinal fasciculus; str, superior thalamic radiation; unc, uncinate fasciculus. Group-differences are significant at a threshold of p < .05 using two-sample t-tests.

Bold values mean there is a significant statistical difference.