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. 2021 Apr 12;12:624404. doi: 10.3389/fphar.2021.624404

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Copyright © 2021 Xuan, Xi, Zhang, Tao, Zhang and Cao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Yiqi Jiedu Huayu decoction (YJHD) improves diabetic symptoms and renal function. (A) Timeline of animal experiments. (B–D) Changes in body weight and 24-h food and water intake of rats during drug intervention (recorded every 4°weeks). (E) Changes in blood glucose before and after drug intervention. (F, G) Changes in 24-h urine volume and 24-h urinary protein quantification during drug intervention (measured every 4°weeks). (H, I) Serum creatinine (Cr) and blood urea nitrogen (BUN) levels after drug intervention. (J) Serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels after drug intervention. The data are expressed as ****p < 0.0001: compared with the normal control group; #p < 0.05, ##p < 0.01, and ####p < 0.0001: compared with the diabetic group, respectively.