Table 2.
Clinical outcomes within the 28 days after inclusion
| Total population (n = 191) | Responders (n = 96) | Non-responders (n = 95) | P | |
|---|---|---|---|---|
| PaO2/FiO2 response to prone positioning (%, mmHg) | 49 [19–100] | 100 [67–155] | 19 [3–31] | < 0.001 |
| Duration of prone positioning (hours) | 16 [16–17] | 16 [16–16.7] | 16 [16–17] | 0.757 |
| Tracheostomy—no (%) | 113 (59.2) | 46 (47.9) | 67 (70.5) | 0.008 |
| Duration of MV, days | 18 [11–28] | 18 [10–27] | 18 [12–29] | 0.432 |
| Attempted extubation—no (%) | 39 (20.4) | 33 (34.3) | 6 (6.3) | < 0.001 |
| Weaning failure—reintubation no (%) | 22 (18.8) | 17 (17.7) | 5 (5.3) | 0.093 |
| VAP—no (%) | 105 (55) | 53 (55.2) | 52 (54.7) | 0.885 |
| Steroid use | 133 (70%) | 72 (75%) | 61 (64%) | 0.083 |
| Non pulmonary infections—no (%) | 72 (37.7) | 37 (38.5) | 35 (36.8) | 0.882 |
| Cardiovascular complications—no (%) | 31 (16.2) | 13 (13.5) | 18 (18.9) | 0.333 |
| Digestive complications—no (%) | 8 (4.2) | 5 (5.2) | 3 (3.2) | 0.721 |
| Neurologic complications—no (%) | 17 (8.9) | 9 (9.4) | 8 (8.4) | 1.000 |
| Renal Replacement therapy—no (%) | 43 (22.5) | 22 (22.9) | 21 (22.1) | 1.000 |
| Veno-venous ECMO—no (%) | 3 (1.6) | 0 (0.0) | 3 (3.2) | 0.121 |
| ICU length of stay, days | 22 [14–35] | 22[15–35] | 21[14–35] | 0.994 |
| VFD at 28 days, days | 4.5 ± 7.1 | 6.3 ± 8.1 | 2.7 ± 5.6 | < 0.001 |
| ICU mortality—no (%) | 83 (43.4) | 32 (33.3) | 51 (53.7) | 0.006 |
Values are median (IQR) except for VFD (Mean ± SD). Significant P values are highlighted in bold
FiO2 inspired fraction of oxygen, CRS respiratory system compliance measured in supine position, PaO2 arterial oxygen partial pressure, MV mechanical ventilation, NIV non-invasive ventilation, CPAP continuous positive airway pressure, HFNO high flow nasal oxygen, VFD ventilator free days, VAP ventilator associated pneumonia, DP driving pressure