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. 2021 Apr 12;11:656078. doi: 10.3389/fonc.2021.656078

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Copyright © 2021 Mo, He, Zheng, Chen, Tang and Yan

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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tRF-17-79MP9PP directly regulates THBS1 expression in breast cancer cells. THBS1 mRNA (A) and protein (B) levels expression in treated MCF-7 and BT549 cells, respectively. (C) 3’-UTR fragment of wide-type (wt) and mutated which disrupted interaction with tRF-17-79MP9PP. (D) The wt or mutated reporter plasmid was co-transfected with tRF-17-79MP9PP mimics/inhibitor and negative control into HEK293T cells. Luciferase activity of wt THBS1 3’-UTR was significantly influenced by tRF-17-79MP9PP in cells. *p < 0.05; ** p < 0.01, statistically significant.