Figure 5.

B cells are important for maintaining BCL6 expression in Tfh cells. (A) 2x10⁶ CD4⁺ T cells were sorted from 8 week-old IL4^KN2/+ and IL4^KN2/+LAT^m/m mice. Cells were i.v injected into LAT^-/- or RAG^-/- recipient mice for 8 wks. (B) BCL6 and huCD2 expression on CD4⁺Thy1.2⁺ transferred T cells. (C) The percent of BCL6⁺huCD2⁺ cells and intensity of BCL6 staining. Data are representative of 2-3 individual experiments. Two-tailed t test; *p < 0.05.