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. 2021 Apr 12;12:656817. doi: 10.3389/fimmu.2021.656817

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Copyright © 2021 O’Brien, Zhu and Zhang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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ICOS signaling is not required for Tfh development in LATY136F mice. WT, LAT^m/m, ICOS^-/-, and ICOS^-/-LAT^m/m mice were all bred to IL4^KN2/+ mice and were analyzed at 6-8 weeks of age. (A) CD4 and CD8 expression on splenocytes. (B) Surface staining of CD4 and huCD2. (C) Surface expression of CXCR5 and PD1. (D) Intracellular staining of BCL6. (E) GATA3 levels and gMFI. Cells were pre-gated on CD4⁺ T cells (B–E). (F) Absolute numbers of CD4⁺ T cells and CD4⁺BCL6⁺ T cells. Data are representative of two individual experiments.