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. 2021 Feb 1;9(2):100312. doi: 10.1016/j.esxm.2020.100312

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© 2020 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

The effect of HFD and oral MJ extract on α-smooth muscle actin expression within the corpora cavernosa. Alpha smooth muscle actin antibody (α-SMA), a surrogate for myofibroblast expression, with AEC as chromogen and counterstaining with hematoxylin. Top panel: A: Control NCD; B: NCD + MJ; C: NCD + THC; Middle panel: D: Control HFD; E: HFD + MJ; F: HFD + THC. Bottom panel: QIA analysis of (α-SMA) determined at the level of the sinusoids and of the total corpora cavernosa. QIA results are expressed as %α-SMA IOD area/total area mean ± SEM: NCD + MJ vs control NCD (∗∗∗P < .001), HFD + MJ vs control HFD (∗∗P < .01) in the sinusoids; HFD + MJ vs control NCD or HFD (∗P < .05) and NCD + MJ vs HFD + MJ (#∗∗P < .05) in the tunica albuginea. Localization of α-SMA as demonstrated arrows. Thin arrows indicate the presence of myofibroblasts within the SMCs in the sinusoid (S) area. Thick arrows indicate the presence of myofibroblasts in the tunica albuginea (TA), which is pronounced in HFD groups. THC added to either NCD or HFD did not lead to significant changes in α-SMA expression at the sinusoid or tunica albuginea levels compared to control NCD or HFD. Magnification = 100×; 1 bar = 100 μm.