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. 2021 Feb 1;9(2):100312. doi: 10.1016/j.esxm.2020.100312

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© 2020 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

The effect of HFD and oral MJ extract on heme oxygenase 1 expression. Heme oxygenase 1 (HO-1), a marker of antioxidative expression, within the cavernosa was determined by immunohistochemistry. Top panel: A: Control NCD; B: NCD + MJ; C: NCD + THC; Middle panel: D: Control HFD; E: HFD + MJ; F: HFD + THC. Bottom panel: QIA evaluation as %HO-1 cells/total cells means ± SEM. HO-1 expression was significantly reduced in the corpora of HFD + MJ group compared to the control NCD or HFD group (∗∗∗P < .001, ∗∗P < .01 respectively). A reduction in HO-1 expression was also seen in NCD + THC vs control NCD and HFD + THC vs control HFD (∗P < .05). Magnification = 100×; 1 bar = 100 μm.