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. 2021 Apr 28;27(16):1785–1804. doi: 10.3748/wjg.v27.i16.1785

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©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.

This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.

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Proteomic and bioinformatic analysis of identified proteins. A: A total of 5993 proteins were identified by isobaric tags for relative and absolute quantification. Red circle indicates 100 differentially expressed proteins (DEPs); B: The result of Gene Ontology annotation. The identified proteins were categorized into three types: Biological process, molecular function, and cellular component; C: Enriched Gene Ontology annotation statistics of DEPs; D: Enriched KEGG pathway statistics of DEPs; E: Protein cluster analysis of DEPs. The red box part is AGR2, PICK1, and BCL-XL. shCtrl: Negative control virus; shMRPL35: Lentiviral particles of MRPL35.