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Working model of CSNK2A1 role in cilia homeostasis and function. CSNK2A1 acts as a negative regulator of TTBK2 and SHH signaling. It is differentially enriched at the mother centriole and the distal appendages. The kinase knockout leads to the aberrant trafficking of several critical regulators of cilia assembly, SHH pathway, and actin dynamics. The red shading on the ciliary membrane illustrates the part that will be decapitated.
