Table 2.

CAD-related miRNAs whose function has been assessed in myocardial cells or vascular smooth muscle cells.

microRNA	Samples	Expression pattern	Assessed cell lines	Gene/protein interactions	Signaling pathway	Function	References
miR-574-5p	Serum samples from 32 CAD patients and 30 normal individuals	Up-regulated	VSMCs	ZDHHC14	–	Suppresses apoptosis and promotes cell proliferation in VSMCs through targeting ZDHHC14	(27)
miR-146a	20 female Sprague-Dawley rats	Up-regulated	Myocardium	–	–	Injection of endothelial stem cell to rats with acute myocardial infarction caused decreased miR-146a expression and decreased cardiac apoptosis	(28)
miR-93	male C57BL/6 mice established as myocardial infarction (MI) models	Up-regulated	Cardiomyocytes	–	–	Suppresses apoptosis and promotes angiogenesis. Also has antioxidant effects	(29)
miR-448	atherosclerosis plaques and normal coronary artery tissues	Up-regulated	VSMCs	MEF2C	–	Promotes migration and proliferation of VSMCs by targeting MEF2C	(30)