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. 2021 Apr 12;8:656047. doi: 10.3389/fmed.2021.656047

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Copyright © 2021 Delbue, Lebenheim, Cardoso-Silva, Dony, Krug, Richter, Manna, Muñoz, Wolk, Heldt, Heimesaat, Sabat, Siegmund and Schumann.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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IL-22 exposure causes atypical cysts formation. (A) CaCo-2 cells were seeded in Matrigel® and grown for 5–7 days to form 3D cysts. Subsequently, they were fixed and immunostained. Blue, nuclei; red, actin; green, E-cadherin. Representative images n = 6. (B–D) Quantification of the 3D-cyst experiments: CaCo-2 cysts growing in Matrigel® were analyzed by confocal LSM. Multilumen, hollow cysts and cysts revealing mitoses were microscopically quantified; n = 6. Mann–Whitney U-test; *p < 0.05; **p < 0.01.