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. 2021 Apr 12;12:665147. doi: 10.3389/fimmu.2021.665147

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Copyright © 2021 Wu, Xie, Wang, Li, Han, Qin, Zhang, Wu, Gao, Zhang, Wei, Liu and Jiao

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Cytokines are associated with the response of combination therapy in responder (R)/non-responder (NR) patients and patients with clinical benefit/no clinical benefit (NCB). (A) Comparison of 27 cytokines in R patients and NR patients at different time points and different ratios in the volcano map. (B) Comparison of 27 cytokines in CB and NCB patients at different time points and different ratios in the volcano map. Cytokines with a log₂ |fold-change| greater than 1.0 and a −log10 (P-value) greater than 1.3 were considered significant.