Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Apr 12;12:640061. doi: 10.3389/fphys.2021.640061

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2021 Doronzo, Astanina and Bussolino.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Signaling mechanisms regulating TFEB nuclear translocation in normal (A) and stressed conditions (B). (A) TFEB binds GTP- RagGTPase on the surface of lysosome followed by the recruitment of Raptor and mTOR. This complex allows the phosphorylation of TFEB, which interacts with 14-3-3 adaptor with subsequent degradation. (B) In stressed conditions, calcium ions released from lysosomes through mucolipin 1 channel activates the protein phosphatase calcineurin, (CN) which dephosphorylates TFEB, allowing its nuclear translocation.