. 2021 Apr 16;118(16):e2103254118. doi: 10.1073/pnas.2103254118

Table 1.

Results of metaregression of association between famine cohort (F1) TB incidence rate ratio (IRR) and famine intensity (CSSI) across alternative famine intensity estimators

CSSI estimator	Type	Trend	Data used to fit model	Adjustments	Median CSSI (interquartile range)	Estimated log change TB F1 IRR per 100% increase in CSSI (95% CI)
$C S S I_{p r e_f i x e d}$	Average	None	1953–1957 cohort	None	0.39 (0.34–0.45)	0.41 (−0.02–0.84)
$C S S I_{p r e_p o s t_m e a n}$	Average	15 y linear	1953–1957, 1963–1967 cohorts	None	0.49 (0.44–0.52)	0.76 (0.14–1.38)
$C S S I_{p r e_p o s t_m e a n_a d j u s t e d}$	Average	15 y linear	1953–1957, 1963–1967 cohorts, 1952–1970 fertility data	Potential delayed births subtracted from postfamine cohort	0.47 (0.42–0.51)	0.75 (0.14–1.37)
$C S S I_{p r e_5_p o s t_5_l m}$	Linear model	25 y linear	1948–1952, 1968–1972 cohorts	Cohorts adjusted for survival from 1964 to 2000	0.50 (0.46–0.54)	0.95 (0.16–1.73)
$C S S I_{p r e_53_p o s t_5_g a m}$	Generalized additive model	Smoothly varying	1900–1952, 1968–1972 cohorts	Cohorts adjusted for survival from 1964 to 2000	0.45 (0.42–0.51)	0.93 (0.17–1.68)
$C S S I_{p r e_10_p o s t_10_l m}$	Linear model	35 y linear	1943–1952, 1968–1977 cohorts	Cohorts adjusted for survival from 1964 to 2000	0.45 (0.40–0.49)	0.82 (−0.03–1.67)
$C S S I_{p r e_53_p o s t_10_g a m}$	Generalized additive model	Smoothly varying	1900–1952, 1968–1977 cohorts	Cohorts adjusted for survival from 1964 to 2000	0.43 (0.39–0.46)	0.78 (−0.10–1.67)