Table 3.
Optimal cutoff values for each parameter and its sensitivity, specificity and likelihood ratio distinguishing unilateral PA patients without apparent adrenal tumors from bilateral PA patients.
| Parameters | Optimal Cutoff Value | Sensitivity | Specificity | Positive Likelihood Ratio | Negative Likelihood Ratio |
|---|---|---|---|---|---|
| Age, years | 55 | 51.5 | 60.1 | 1.29 | 0.81 |
| HT duration, years | 8 | 93.7 | 15.2 | 1.10 | 0.42 |
| Creatinine, mg/dL | 0.74 | 64.5 | 58.5 | 1.55 | 0.61 |
| Serum K+, mEq/L | 3.7 | 78.9 | 61.5 | 2.05 | 0.34 |
| ARR, pg/ml per ng/ml/h | 559 | 68.0 | 66.7 | 2.04 | 0.48 |
| PAC, pg/ml | 223 | 53.0 | 77.9 | 2.39 | 0.60 |
| Sex, male | – | 71.5 | 56.6 | 1.65 | 0.50 |
| Low eGFR | – | 16.0 | 88.9 | 1.44 | 0.94 |
| Proteinuria | – | 17.0 | 92.6 | 2.30 | 0.90 |
| Hypokalemia | – | 62.0 | 83.1 | 3.67 | 0.46 |
| CVD | – | 10.0 | 93.8 | 1.61 | 0.96 |
For continuous variables, the optimal cutoff value was determined using the maximum Youden index calculated from the ROC curve. Hypokalemia was considered to be present if K+ was ≤3.5 mEq/L or when a patient was taking a potassium supplement. Low eGFR was defined as eGFR <60 ml/min/1.73m2. ARR, aldosterone-to-renin ratio; CVD, cardiovascular disease; EGFR, estimated glomerular filtration rate; HT, hypertension; PA, primary aldosteronism; and PAC, plasma aldosterone concentration.