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. 2021 Apr 12;12:621935. doi: 10.3389/fimmu.2021.621935

Table 2.

Adverse events.

Subjects with adverse event, n (%) G-CSF PEG-G-CSF p
Any AE during mobilization*
 AE leading to discontinuation
Serious AE after mobilization
Hematological malignancies after mobilization
Most common AEs during mobilization
Bone pain
 Grade 1–2 Grade 3–4
Headache
 Grade 1–2
 Grade 3–4
Injection site reaction
 Grade 1–2
 Grade 3–4
Flu-like symptoms
 Grade 1–2
 Grade 3–4
49 (92.5)
0 (0.0)
0 (0.0)
0 (0.0)
40 (75.5)
33 (62.3)
7 (13.2)
21 (39.6)
16 (30.2)
5 (9.4)
48 (90.6)
48 (90.6)
0 (0.0)
4 (7.5)
2 (3.8)
2 (3.8)
72 (86.7)
0 (0.0)
0 (0.0)
0 (0.0)
65 (78.3)
50 (60.2)
15 (18.1)
31 (37.3)
21 (25.3)
9 (10.8)
66 (79.5)
66 (79.5)
0 (0.0)
7 (8.4)
5 (6.0)
2 (2.4)
0.300
-
-
-
0.700
0.814
0.452
0.790
0.532
0.792
0.088
0.088
-
0.853
0.562
0.646

*Adverse events (AEs) that started between the first administration of granulocyte-colony-stimulating factor (G-CSF) and 30 days thereafter were regarded as events that occurred “during” the mobilization period.