Table 2.
Subjects with adverse event, n (%) | G-CSF | PEG-G-CSF | p |
---|---|---|---|
Any AE during mobilization* AE leading to discontinuation Serious AE after mobilization Hematological malignancies after mobilization Most common AEs during mobilization Bone pain Grade 1–2 Grade 3–4 Headache Grade 1–2 Grade 3–4 Injection site reaction Grade 1–2 Grade 3–4 Flu-like symptoms Grade 1–2 Grade 3–4 |
49 (92.5) 0 (0.0) 0 (0.0) 0 (0.0) 40 (75.5) 33 (62.3) 7 (13.2) 21 (39.6) 16 (30.2) 5 (9.4) 48 (90.6) 48 (90.6) 0 (0.0) 4 (7.5) 2 (3.8) 2 (3.8) |
72 (86.7) 0 (0.0) 0 (0.0) 0 (0.0) 65 (78.3) 50 (60.2) 15 (18.1) 31 (37.3) 21 (25.3) 9 (10.8) 66 (79.5) 66 (79.5) 0 (0.0) 7 (8.4) 5 (6.0) 2 (2.4) |
0.300 - - - 0.700 0.814 0.452 0.790 0.532 0.792 0.088 0.088 - 0.853 0.562 0.646 |
*Adverse events (AEs) that started between the first administration of granulocyte-colony-stimulating factor (G-CSF) and 30 days thereafter were regarded as events that occurred “during” the mobilization period.