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. 2021 Mar 9;3(2):fcab024. doi: 10.1093/braincomms/fcab024

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© The Author(s) (2021). Published by Oxford University Press on behalf of the Guarantors of Brain.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Area of white matter and lateral ventricles, and numbers of Olig-2 and CC1-positive oligodendrocytes. Left panels: total white matter and ventricle areas. Middle panels: Numbers of total (Olig-2) oligodendrocytes in the parietal (IGWM1/2, PVWM) and temporal (peri-lesion) lobes. Right panels: Numbers of mature (CC1) oligodendrocytes in the parietal (IGWM1/2, PVWM) and temporal (peri-lesion) lobes. Sham occlusion is shown in white columns, UCO is shown in grey columns. Three-way ANOVA including time and the three regions (IGWM1/2 and PVWM) as repeated measures showed a significant reduction in CC1 positive oligodendrocytes in the UCO groups in the parietal lobe regions (P < 0.05). Two-way ANOVA including time as a repeated measure showed a significant reduction in CC1 and Olig-2-positive oligodendrocytes in the UCO groups within the peri-lesion region of the temporal lobe (P < 0.05). Statistical significance shown on the figure was determined on individual time-points by one-way ANOVA for total areas and the peri-lesion region (^#P < 0.05 sham versus UCO) and two-way ANOVA for the parietal lobe with area (IGWM1/2 and PVWM) as a repeated measure (*P < 0.05 sham versus UCO). Data are means ± SEM. N=Sham/UCO, total white matter and lateral ventricle area: 3d 9/8, 7d 8/8, 14d 9/8, 21d 9/8. Olig-2: 3d 9/9, 7d 8/7, 14d 8/8, 21d 9/9. CC1: 3d 9/9, 7d 7/7, 14d 9/8, 21d 8/9.