Table 1.
Group | Baseline | UCO (5 min) |
UCO (17 min) |
+2 h | +4 h | +6 h | +1 day | +3 days | +7 days | +14 days | +21 days | |
---|---|---|---|---|---|---|---|---|---|---|---|---|
pH | Sham | 7.36 ± 0.01 | 7.36 ± 0.01 | 7.36 ± 0.01 | 7.36 ± 0.01 | 7.35 ± 0.01 | 7.35 ± 0.01 | 7.35 ± 0.01 | 7.34 ± 0.01 | 7.35 ± 0.01 | 7.34 ± 0.01 | 7.33 ± 0.01 |
UCO | 7.35 ± 0.01 | 7.03 ± 0.01* | 6.84 ± 0.01* | 7.29 ± 0.02* | 7.38 ± 0.01 | 7.40 ± 0.01* | 7.36 ± 0.01 | 7.36 ± 0.01 | 7.36 ± 0.01 | 7.35 ± 0.01 | 7.36 ± 0.01* | |
paCO2 (mmHg) | Sham | 48.5 ± 0.7 | 47.1 ± 0.8 | 46.6 ± 0.8 | 47.3 ± 0.9 | 46.1 ± 1.1 | 46.7 ± 0.9 | 48.4 ± 0.7 | 48.4 ± 0.8 | 49.1 ± 0.8 | 48.6 ± 1.0 | 49.4 ± 1.2 |
UCO | 50.7 ± 1.4 | 99.7 ± 2.6* | 136.4 ± 6.0* | 47.8 ± 0.8 | 47.7 ± 1.1 | 48.5 ± 0.7 | 46.3 ± 1.4 | 46.8 ± 1.5 | 49.2 ± 1.8 | 50.6 ± 1.4 | 48.6 ± 1.1 | |
paO2 (mmHg) |
Sham | 25.6 ± 0.6 | 24.6 ± 0.7 | 24.3 ± 0.6 | 25.5 ± 0.7 | 24.9 ± 0.5 | 25.7 ± 0.7 | 26.2 ± 0.8 | 27.0 ± 0.7 | 25.3 ± 1.1 | 26.0 ± 1.4 | 22.6 ± 1.3 |
UCO | 24.7 ± 0.8 | 6.6 ± 0.4* | 9.5 ± 1.2* | 27.2 ± 1.2 | 23.5 ± 1.0 | 25.4 ± 1.0 | 29.1 ± 1.0* | 31.1 ± 1.2* | 29.4 ± 1.5* | 28.4 ± 1.2 | 26.5 ± 1.8 | |
Hct (%) |
Sham | 27.2 ± 0.7 | 26.2 ± 0.8 | 26.1 ± 0.9 | 26.7 ± 0.7 | 25.4 ± 0.7 | 25.9 ± 0.9 | 26.9 ± 0.8 | 29.4 ± 1.4 | 31.6 ± 1.8 | 31.3 ± 1.3 | 31.4 ± 0.8 |
UCO | 26.2 ± 0.7 | 27.8 ± 1.1 | 28.2 ± 0.8 | 28.1 ± 0.7 | 27.4 ± 0.5* | 27.7 ± 0.8 | 29.0 ± 0.5* | 30.2 ± 2.2 | 33.6 ± 3.7 | 35.2 ± 4.4 | 30.5 ± 1.2 | |
O2ct (mmol/l) |
Sham | 3.6 ± 0.1 | 3.4 ± 0.1 | 3.3 ± 0.2 | 3.6 ± 0.1 | 3.2 ± 0.1 | 3.4 ± 0.2 | 3.7 ± 0.2 | 3.9 ± 0.1 | 3.9 ± 0.2 | 6.6 ± 2.7 | 3.3 ± 0.3 |
UCO | 3.6 ± 0.1 | 0.4 ± 0.1* | 0.5 ± 0.1* | 4.3 ± 0.3* | 3.6 ± 0.2 | 4.1 ± 0.2* | 4.5 ± 0.1* | 4.6 ± 0.2* | 4.6 ± 0.2* | 4.5 ± 0.2 | 4.2 ± 0.2* | |
Lactate (mmol/l) |
Sham | 0.9 ± 0.1 | 0.9 ± 0.03 | 0.9 ± 0.1 | 0.9 ± 0.0 | 0.9 ± 0.0 | 1.0 ± 0.0 | 0.9 ± 0.1 | 0.8 ± 0.04 | 0.9 ± 0.0 | 0.8 ± 0.0 | 1.1 ± 0.1 |
UCO | 0.8 ± 0.1 | 3.9 ± 0.2* | 6.2 ± 0.3* | 4.8 ± 0.7* | 3.0 ± 0.5* | 2.1 ± 0.2* | 1.5 ± 0.2* | 0.9 ± 0.1 | 0.7 ± 0.0* | 0.8 ± 0.0 | 0.8 ± 0.0 | |
Glucose (mmol/l) | Sham | 1.1 ± 0.1 | 1.0 ± 0.04 | 1.0 ± 0.1 | 1.2 ± 0.1 | 1.1 ± 0.1 | 1.2 ± 0.1 | 1.1 ± 0.1 | 1.0 ± 0.1 | 1.0 ± 0.1 | 0.8 ± 0.1 | 0.8 ± 0.1 |
UCO | 1.0 ± 0.1 | 0.4 ± 0.1* | 0.6 ± 0.1* | 1.3 ± 0.1 | 1.3 ± 0.1 | 1.4 ± 0.1* | 1.4 ± 0.1* | 1.1 ± 0.1 | 0.9 ± 0.1 | 0.9 ± 0.1 | 0.9 ± 0.0 |
paCO2, arterial partial pressure of carbon dioxide; paO2, arterial partial pressure of oxygen; Hct, haematocrit; O2ct; arterial oxygen content.
P < 0.05 sham versus UCO. Data are means ± SEM.