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Role of pDC-type I IFN axis in allergy. PDCs have a protective role in the development of allergic diseases via secreting type I IFNs, which help to maintain a healthy Th1–Th2 balance and prevent the shift towards Th2 dominance in the airways. IFN: interferon; IgE: immunoglobulin E; ILC2: type 2 innate lymphoid cells; pDC: plasmacytoid dendritic cell; Th: T helper; Treg: regulatory T cell.
