Table 2.

General overview of miRNAs involved in differentiating myoblasts state. Arrows indicate miRs that are expressed (↑) or downregulated (↓) within each cell stage.

Differentiating Myoblasts State
miR-1↑, miR-206↑, and miR-29↑	Hdac4	Promotes myoblast differentiation	[54,77]
miR-1↑ and miR-206↑	Gja1	Promote myoblast fusion	[74]
miR-1↑ and miR-206↑	Pax7	Promote satellite cell differentiation and restrict their proliferative potential	[17]
miR-206↑	Pax7	Activates myoblast differentiation	[75]
miR-206↑	Pax7, Notch3, and Igfbp5	Stimulates SC differentiation and skeletal muscle regeneration	[76]
miR-206↑	Pola1	Promotes myoblast differentiation by inducing a cell cycle arrest	[78]
miR-486↑	Pax7	Promote initial muscle differentiation	[75]
miR-486↑	Pdgfrβ, Pten, Pik3r1, Foxo1, Sfrs1, and Sfrs3	Promotes myoblast differentiation by inhibiting PTEN/AKT pathway and splicing factors	[80]
miR-431↑	Pax7	Mediates satellite cell heterogeneity and promotes muscle differentiation	[79]
miR-133↑	Fgfr1 and Pp2ac	Promotes muscle precursor cells differentiation	[82]
miR-27b↑	Pax3	Ensures rapid and robust entry into the myogenic differentiation program	[83]
miR-29↑	Rybp and Yy1	Ensures proper myoblast differentiation into myotubes	[85,86]
miR-29↑	Akt3	Reduces proliferation and facilitate differentiation of precursor muscle cells	[87]
miR-26a↑	Smad1 and Smad4	Promotes myoblast differentiation	[88]
miR-26a↑ and miR-214↑	Ezh2	Induces muscle cell differentiation	[91,92]
miR-214↑	N-ras	Promotes myogenic differentiation by facilitating exit from mitosis	[93]
miR-146b↑	Smad4, Notch1, and Hmga2	Promotes myogenic differentiation	[94]
miR-675-3p↑	Smad1 and Smad5	Promotes myogenic differentiation downregulates the BMP pathway	[99]
miR-675-5p↑	Cdc6	Promotes myogenic differentiation by repression of DNA replication	[99]
miR-181↑	HoxA11	Promotes myogenic differentiation	[108]
miR-378↑	Msc	Promotes myogenic differentiation	[109]
miR-205a↑	Cdh11	Inhibits myoblast proliferation and promote myoblast differentiation	[110]
miR-17↑	Ccnd1, Ccnd2, Jak1, and Rhoc	Promotes differentiation of precursor muscle cells by inducing cell cycle arrest and extracellular matrix expression	[100]
miR-34b↑	Igfbp2	Represses proliferation and promotes differentiation of myoblasts	[106]
miR-34c↑	Yy1	Represses proliferation and promotes differentiation of myoblasts by leading to G0/G1 arrest	[107]
miR-664↑	Wnt1	Downregulates Wnt/β-catenin signaling pathway to allow normal myogenic differentiation	[55]
miR-199a↑	Wnt2, Fzd4, and Jag1	Downregulates Wnt/β-catenin signaling pathway to allow normal myogenic differentiation	[111]
miR-155↓	Mef2a	Represses myoblast differentiation	[115]
miR-487b↓	Irs1	Suppresses the proliferation and differentiation of myoblasts by repressing PI3K/Akt and MAPK/Erk pathways	[68]
miR-221 and 222↓	Cdkn1b	Inhibits myoblast differentiation by allowing myoblast to proliferate and avoiding to acquire myotube morphology	[112]
miR-351↓	Lactb	Represses myoblast differentiation	[113]
miR-125b↓	Igf2	Represses myoblast differentiation	[118]
miR-186↓	Myog	Represses myoblast differentiation	[119]
miR-23a↓	Myh1, Myh2, and Myh4	Prevents myogenic differentiation by inhibiting myosin genes expression	[120]