Table 3.

Experimental strategies assayed to modulate miRNAs expression in the context of DMD in order to improve SCs behavior and fibrosis.

Muscle Regeneration Event	Target microRNA	Molecular Approach	Experimental System	Reference
Duchenne Muscular Dystrophy
Fibrosis and Inflammation	miR-29	miRNA Mimic	Human DMD myoblast	[130]
		miRNA Mimic	mdx mice	[129]
		miR-29 + micro-dystrophin overexpression by AAV	mdx/utrn+/− mice	[131]
	miR-206	AntagomiR Sponge	mdx mice	[132]
	miR-21	AntagomiR	Human DMD fibroblasts Mdx mice	[130]
		AntagomiR	Senescence mdx mice	[133]
	miR-146a	KO	mdx mice	[134]
Muscle differentiation	miR-29	miRNA Mimic	Human DMD myoblast	[130]
		miRNA Mimic	mdx mice	[129]
	miR-31	AntagomiR or Sponges + exon skipping	Human DMD myoblasts	[135]
	miR-431	Transgenic overexpression	mdx mice	[79]
	miR-127	siRNA mimic Transgenic overexpression	C2C12 myoblasts mdx mice	[136]