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. 2021 Apr 17;8(4):49. doi: 10.3390/bioengineering8040049

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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The schematics of the developed dual-functional plasmonic biosensor. (A) the overall structure of the sensor combining the PPT effect and LSPR for detection of the virus genetic material. (B) The dual-functional PPT enhanced LSPR biosensing system including the aperture-iris (I1/I2), the linear polarizers (P1/P2), the birefringent crystal (BC), and totally reflected at the interface of AuNI-dielectric for LSPR detection. A laser diode (LD) generates the PPT effect on AuNIs. (C) AuNI functionalization based on the reaction with thiol-cDNA ligands. (D) Illustration of the hybridization between two complementary strands, the reporter DNA, and the target sequence in SARS-CoV-2 genome. (E) Specific hybridization of the functionalized thiol-cDNA and inhibiting partial adhesion of RdRp-SARS sequence with two mismatches.