Table 3.
Characteristics of breast cancer cell lines with different molecular subtypes (adopted from Dai, X et al. 2017) [131].
| Cell Line | ER | PR | HER2/neu+ | Subtype | BRAC1 Mutation | p53 Mutation | Tumor |
|---|---|---|---|---|---|---|---|
| CAMA-1 | + | +/- | - | LA | WT | MU | AC |
| HCC1428 | + | + | - | LA | ND | ND | AC |
| MCF-7 | + | - | - | LA | ND | WT | IDC |
| MDA-MB-134 | + | - | - | LA | ND | MU | IDC |
| T-47D | + | + | - | LA | WT | MU | IDC |
| ZR75-1 | + | +/- | - | LA | WT | WT | IDC |
| BT-474 | + | + | + | LB | WT | MU | IDC |
| ZR75-30 | + | - | + | LB | WT | WT | IDC |
| MDA-MB-453 | - | - | + | Her2+ | WT | MU | AC |
| SK-BR-3 | - | - | + | Her2+ | WT | MU | AC |
| SK-BR-5 | - | - | + | Her2+ | WT | MU | AC |
| BT-20 | - | - | - | TNBC | WT | MU | IDC |
| BT-549 | - | - | - | TNBC | WT | MU | IDC |
| CAL-51 | - | - | - | TNBC | WT | MU | AC |
| CAL-148 | - | - | - | TNBC | WT | MU | AC |
| HCC1937 | - | - | - | TNBC | MU | MU | DC |
| Hs578T | - | - | - | TNBC | WT | MU | IDC |
| MDA-MB-157 | - | - | - | TNBC | WT | MU | MC |
| MDA-MB-231 | - | - | - | TNBC | WT | MU | AC |
| MDA-MB-435 | - | - | - | TNBC | WT | MU | AC |
| MDA-MB-436 | - | - | - | TNBC | MU | MU | AC |
| MDA-MB-468 | - | - | - | TNBC | WT | MU | AC |
| SK-BR-7 | - | - | - | TNBC | WT | WT | AC |
WT: wild type; ND: not decided; MU: BRCA1 mutation; AC: adenocarcinoma; DC: ductal carcinoma; IDC: invasive ductal carcinoma; LA: luminal A; LB: luminal B; HER2+: human epidermal growth factor receptor 2-positive; TNBC: triple-negative breast cancer.