TABLE 3.
Effect of treatment with the bacteriophages on the level of serum biochemical analysis in Charles foster rats.
| Parameters | Experimental treatment groups | |||
|---|---|---|---|---|
| G1 | G2 | G3 | Normal Ref. Range Alemán et al. (1998) | |
| TB (mg/dl) | 0.14 ± 0.02 | 0.09 ± 0.02 | 0.12 ± 0.01 | 0.05–0.15 |
| SGOT (U/L) | 146.88 ± 8.75 | 180.90 ± 12.26 | 186.43 ± 21.10 | 150–190 |
| SGPT (U/L) | 53.13 ± 8.13 | 37.38 ± 1.21 | 43.37 ± 11.66 | 60–90 |
| ALP (U/L) | 164.25 ± 24.09 | 159.59 ± 11.76 | 148.39 ± 13.16 | 62–230 |
| CK-MB (U/L) | 185.00 ± 26.89 | 226.40 ± 18.19 | 209.75 ± 21.88 | 162–1184 |
| TP (g/dl) | 6.21 ± 0.05 | 7.11 ± 0.33 | 8.13 ± 0.91 | 5.2–7.1 |
| A (g/dl) | 2.70 ± 0.39 | 3.78 ± 0.15 | 3.91 ± 0.32 | 3.4–4.8 |
| G (g/dl) | 2.96 ± 0.04 | 3.05 ± 0.02 | 2.57 ± 0.02 | 1.5–2.5 |
| A/G ratio | 1.10 ± 0.02 | 1.10 ± 0.02 | 1.26 ± 0.02 | 1.58–2.67 |
| Creatinine (mg/dl) | 0.58 ± 0.10 | 0.68 ± 0.02 | 0.64 ± 0.02 | 0.2–0.5 |
| Uric acid (mg/dl) | 0.81 ± 0.06 | 0.98 ± 0.04 | 1.21 ± 0.08 | 0.5–1.4 |
| Blood urea (mg/dl) | 29.53 ± 2.55 | 40.40 ± 3.17 | 34.90 ± 3.64 | 12.3–24.6 |
| Calcium (mg/dl) | 9.76 ± 0.37 | 10.51 ± 0.07 | 11.64 ± 0.18 | 9.5–11.5 |
| Phosphorus (mg/dl) | 6.71 ± 0.58 | 7.85 ± 0.65 | 7.79 ± 0.76 | 5.58–10.41 |
| Na+ (mmol/L) | 137.95 ± 2.99 | 134.68 ± 4.06 | 130.70 ± 10.30 | 142–151 |
| K+ (mmol/L) | 7.67 ± 1.61 | 6.15 ± 0.53 | 5.61 ± 0.69 | 3.82–5.55 |
| Cl- (mmol/L) | 99.95 ± 5.54 | 96.68 ± 2.37 | 91.05 ± 2.30 | 90–106 |
| Glucose (mg/dl) | 111.25 ± 5.48 | 149.48 ± 8.56 | 152.62 ± 18.38 | 70–208 |
| TC (mg/dl) | 88.52 ± 5.34 | 117.46 ± 6.75 | 110.17 ± 5.43 | 37–85 |
| Triglyceride (mg/dl) | 97.38 ± 7.54 | 109.08 ± 10.13 | 118.56 ± 14.70 | 20–120 |
| HDL (mg/dl) | 65.17 ± 2.84 | 73.11 ± 5.11 | 77.21 ± 1.79 | 55–80 |
| LDL (mg/dl) | 15.39 ± 1.88 | 14.16 ± 1.03 | 22.69 ± 1.34 | 15–24 |
| VLDL (mg/dl) | 24.50 ± 3.57 | 28.00 ± 7.05 | 25.00 ± 3.32 | 18–28 |
G: Group; G1: Normal control (TMG); G2: Medium oral dose of bacteriophage (1015/ml), and G3: High oral dose of bacteriophage (1020/ml); No significant difference could be found among the different groups (p < 0.005). All the values are presented as mean ± SEM (n = 6). No significant difference could be found among the different groups (p > 0.05). The normal reference ranges of serum biochemical parameters were mentioned and compared as per animal Clinical Laboratory Parameters.