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. 2021 Apr 19;11(4):315. doi: 10.3390/jpm11040315

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Key structures of the mesocorticolimbic system include the ventral tegmental area (VTA); ventral striatum (VS); hippocampus (Hippo); amygdala (AMG); thalamus; insula; hypothalamus; and cortical regions, including the dorsal anterior cingulate cortex (dACC), medial prefrontal cortex (mPFC), orbitofrontal cortex (OFC), and dorsal prefrontal cortex (dPFC). Additional structures shown on the figure are the ventral pallidum (VP), lateral habenula (LHb), subthalamic nucleus (STN), substantia nigra (SN), and pedunculopontine nucleus (PPT). Adapted from Haber and Knutson, 2010.