Table 4.

Physicochemical properties, pharmacokinetics and drug-likeness of identified compounds according to SwissADME software.

Entry	1	3	5	6	7	8	10	12	13	14	15	17
GI absorption	Low	High	High	High	Low	High	Low	Low	Low	Low	Low	Low
BBB permeant	No	No	No	No	No	No	No	No	No	No	No	No
P-gp substrate	Yes	No	No	No	No	No	No	No	No	No	No	No
CYP1A2 inhibitor	No	No	Yes	Yes	No	Yes	No	No	No	No	No	No
CYP2C19 inhibitor	No	No	No	No	No	No	No	No	No	No	No	Yes
CYP2C9 inhibitor	No	No	No	No	Yes	No	Yes	Yes	Yes	Yes	Yes	Yes
CYP2D6 inhibitor	No	Yes	Yes	Yes	No	No	No	No	No	No	No	No
CYP3A4 inhibitor	No	Yes	Yes	Yes	No	Yes	No	No	No	No	No	No
Log Kp (cm/s)	−7.65	−6.72	−6.25	−5.80	−8.95	−6.66	−8.39	−8.39	−8.16	−8.16	−8.16	−5.24
Lipinski’s Rule	Yes	Yes	Yes	Yes	Yes	Yes	No	No	No	No	No	Yes
Bioavailability Score	0.55	0.55	0.55	0.55	0.55	0.55	0.17	0.17	0.17	0.17	0.17	0.55