Table 1.
MIC50, MIC90, MIC ranges, and interpretations of LCB10-0200, LCB10-0200/AVI, ATM, ATM-AVI, CAZ, CAZ-AVI, AVI against carbapenem-resistant E. coli, K. pneumoniae, A. baumannii, and P. aeruginosa.
| Species (No. of Isolates, Percentages of Isolates) | MIC Data (mg/L) | MIC Interpretation (%) | ||||
|---|---|---|---|---|---|---|
| MIC50 | MIC90 | Range | Susceptible | Intermediate | Resistant | |
| All isolates (93, 100%) | ||||||
| ATM | 64 | ≥256 | 2–≥256 | NA | NA | NA |
| ATM-AVI | 4 | 64 | ≤0.12–128 | NA | NA | NA |
| CAZ | 128 | ≥256 | 2–≥256 | NA | NA | NA |
| CAZ-AVI | 8 | 64 | ≤0.12–≥256 | NA | NA | NA |
| LCB10-0200 | 1 | 16 | ≤0.12–≥256 | NA | NA | NA |
| LCB10-0200/AVI | 0.5 | 16 | ≤0.12–≥256 | NA | NA | NA |
| AVI | ≥256 | ≥256 | 4–≥256 | NA | NA | NA |
| MEM | 32 | 128 | 2–≥256 | NA | NA | NA |
| Fermenting gram-negative bacilli: E. coli & K. pneumoniae isolates (42) | ||||||
| ATM | ≥256 | ≥256 | 8–≥256 | 0 | 2.4 | 97.6 |
| ATM-AVI | 0.5 | 1 | ≤0.12–16 | NA | NA | NA |
| CAZ | 128 | ≥256 | 2–≥256 | 2.4 | 4.8 | 92.9 |
| CAZ-AVI | 1 | 8 | ≤0.12–≥256 | NA | NA | NA |
| LCB10-0200 | 1 | 16 | ≤0.12–≥256 | NA | NA | NA |
| LCB10-0200/AVI | ≤0.12 | ≤0.12 | ≤0.12–≥256 | NA | NA | NA |
| AVI | 8 | 128 | 4–≥256 | NA | NA | NA |
| MEM | 8 | 64 | 2–≥256 | 0 | 2.4 | 97.6 |
| Non-fermenting gram-negative bacilli: A. baumannii & P. aeruginosa (51) | ||||||
| ATM | 32 | 128 | 2–128 | NA | NA | NA |
| ATM-AVI | 32 | 128 | 2–128 | NA | NA | NA |
| CAZ | 128 | ≥256 | 4–≥256 | 11.6 | 1.9 | 88.5 |
| CAZ-AVI | 32 | 64 | 2–≥256 | NA | NA | NA |
| LCB10-0200 | 0.5 | 16 | 0.12–≥256 | NA | NA | NA |
| LCB10-0200/AVI | 1 | 16 | 0.12–≥256 | NA | NA | NA |
| AVI | ≥256 | ≥256 | ≥256 | NA | NA | NA |
| MEM | 64 | 128 | 8–≥256 | 0 | 0 | 100 |
| E. coli isolates (15, 16%) | ||||||
| ATM | 32 | 128 | 8–≥256 | 0 | 6.7 | 93.3 |
| ATM-AVI | 0.12 | 4 | 0.12–16 | NA | NA | NA |
| CAZ | 64 | ≥256 | 2–≥256 | 0 | 20 | 80 |
| CAZ-AVI | 1 | ≥256 | ≤0.12–≥256 | 80 | 0 | 20 |
| LCB10-0200 | 2 | ≥256 | ≤0.12–≥256 | NA | NA | NA |
| LCB10-0200/AVI | ≤0.12 | ≥256 | ≤0.12–≥256 | NA | NA | NA |
| AVI | 16 | 128 | 4–128 | NA | NA | NA |
| MEM | 8 | 16 | 4–16 | 0 | 0 | 100 |
| K. pneumoniae isolates (27, 29%) | ||||||
| ATM | ≥256 | ≥256 | 128–≥256 | 0 | 0 | 100 |
| ATM-AVI | 0.5 | 0.5 | 0.12–2 | NA | NA | NA |
| CAZ | 128 | 128 | 32–≥256 | 0 | 0 | 100 |
| CAZ-AVI | 1 | 2 | ≤0.12–16 | 96.3 | NA | 3.7 |
| LCB10-0200 | 1 | 8 | ≤0.12–16 | NA | NA | NA |
| LCB10-0200/AVI | 0.12 | 0.12 | ≤0.12–0.25 | NA | NA | NA |
| AVI | 8 | 128 | 8–≥256 | NA | NA | NA |
| MEM | 8 | 128 | 2–≥256 | 0 | 3.7 | 96.3 |
| KPC-producing E. coli & K. pneumoniae isolates (32) | ||||||
| ATM | ≥256 | ≥256 | 16–≥256 | 0 | 0 | 100 |
| ATM-AVI | 0.5 | 0.5 | ≤0.12–2 | NA | NA | NA |
| CAZ | 128 | 128 | 8–≥256 | 0 | 3.1 | 96.9 |
| CAZ-AVI | 1 | 2 | ≤0.12–16 | 96.9 | 3.1 | 0 |
| LCB10-0200 | 1 | 8 | ≤0.12–16 | NA | NA | NA |
| LCB10-0200/AVI | ≤0.12 | ≤0.12 | ≤0.12–0.25 | NA | NA | NA |
| AVI | 8 | 128 | 4–≥256 | NA | NA | NA |
| MEM | 16 | 128 | 2–≥256 | 0 | 3.1 | 96.9 |
| A. baumannii isolates (25, 27%) | ||||||
| ATM | 64 | 128 | 32–128 | NA | NA | NA |
| ATM-AVI | 64 | 128 | 16–128 | NA | NA | NA |
| CAZ | ≥256 | ≥256 | 16–≥256 | 0 | 4 | 96 |
| CAZ-AVI | 32 | 64 | 4–≥256 | NA | NA | 94 |
| LCB10-0200 | 1 | 4 | 0.25–8 | NA | NA | NA |
| LCB10-0200/AVI | 1 | 4 | 0.5–4 | NA | NA | NA |
| AVI | ≥256 | ≥256 | ≥256 | NA | NA | NA |
| MEM | 64 | 128 | 32–128 | 0 | 0 | 100 |
| P. aeruginosa isolates (26, 28%) | ||||||
| ATM | 32 | 64 | 2–64 | 34.6 | 7.7 | 57.7 |
| ATM-AVI | 8 | 32 | 2–64 | NA | NA | NA |
| CAZ | 64 | ≥256 | 4–≥256 | 23.1 | NA | 76.9 |
| CAZ-AVI | 16 | 64 | 2–≥256 | 46.2 | NA | 53.8 |
| LCB10-0200 | 0.5 | 32 | 0.12–≥256 | NA | NA | NA |
| LCB10-0200/AVI | 0.5 | 32 | 0.12–≥256 | NA | NA | NA |
| AVI | ≥256 | ≥256 | ≥256 | NA | NA | NA |
| MEM | 32 | 64 | 8–≥256 | 0 | 0 | 100 |
| OXA-type producing A. baumannii & P. aeruginosa (46) | ||||||
| ATM | 32 | 128 | 2–128 | NA | NA | NA |
| ATM-AVI | 32 | 128 | 2–128 | NA | NA | NA |
| CAZ | 128 | 256 | 4–≥256 | 13 | 2.2 | 84.8 |
| CAZ-AVI | 32 | 64 | 2–≥256 | 30.4 | 10.9 | 58.7 |
| LCB10-0200 | 0.5 | 4 | ≤0.12–32 | NA | NA | NA |
| LCB10-0200/AVI | 1 | 4 | ≤0.12–32 | NA | NA | NA |
| AVI | ≥256 | ≥256 | ≥256 | NA | NA | NA |
| MEM | 32 | 128 | 8–128 | 0 | 0 | 100 |
Abbreviation: ATM, aztreonam; AVI: avibactam; ATM-AVI: aztreonam/avibactam; CAZ, ceftazidime; CAZ-AVI, ceftazidime/avibactam; MEM, meropenem; NA, Not available.