Table 3.
Multivariate associations between neighborhood deprivation index (NDI) and trimethylamine-N-oxide (TMAO) levels with inflammatory markers, adjusted for ASCVD 10 y risk score and BMI (n = 60).
| NDI | TMAO | |
|---|---|---|
| β (p-Value) | β (p-Value) | |
| TMAO | 0.31 (0.02) | - |
| hsCRP ^^ | 0.03 (0.79) | 0.03 (0.80) |
| IL-1β | 0.49 (<0.001) | 0.35 (0.007) |
| IL-6 | 0.18 (0.17) | −0.02 (0.89) |
| IL-8 | 0.07 (0.60) | 0.46 (<0.001) |
| TNF-α | 0.50 (<0.001) | 0.43 (0.001) |
Bold indicates p-value < 0.05. ^^ hs-CRP was undetectable in one individual (n = 59). ASCVD risk score includes sex, age, race, total cholesterol, HDL-C, systolic blood pressure, personal history of diabetes, personal history of smoking, personal history of treatment for hypertension. ASCVD: atherosclerotic cardiovascular disease; BMI: body mass index; TG: triglyceride; hs-CRP: high-sensitivity C-reactive protein; IL: interleukin; TNF: tumor necrosis factor.