Table 10.
Main findings of studies reporting ClotPro results.
| First Author (COUNTRY) |
Design | n | Ward | Controls | EX-Test | IN-Test | FIB-Test | tPA-Test | Conclusions | Association with the Occurrence of Thrombotic Events Outcomes | Definition of Hypercoagulability Assessed by VET According to the Authors | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| CT (s) | CFT (s) | A(x) (mm) | MCF (mm) | ML (%) | CT (s) | CFT (s) | A(x) (mm) | MCF (mm) | ML (%) | CT (s) | A(x) (mm) | MCF (mm) | CT (s) | MCF (mm) | ML (%) | LT (s) | ||||||||
| Bachler et al. (Austria) [24] |
Retrospective study | 20 | ICU | Reference range established in healthy adults | N | NP | ↑ 1 | ↑ 1 | N | N | NP | ↑ 1 | ↑ 1 | N | N | ↑ 1 | ↑ 1 | N | ↑ 1 | N | ↑ 1 | Hypercoagulable pattern assessed by increased clot amplitude and MCF in all assays. No difference in TE outcomes between patients with impaired fibrinolysis (assessed by a prolonged clot lysis time in tPA assay) and patients with normal clot lysis time | No | Increased MCF. Definition not relying on VET =difficulties in reaching the anti-Xa target range despite high doses of LMWH or elevated D-dimer levels > 2000 µg/L |
| 6/20 | ICU with LT ≤ 393 s | N 2 | NP | N | N | N | N | NP | N | N | N | N | ↑ | ↑ | N | N | N | N | ||||||
| 14/20 | ICU with LT > 393 s | N | ↑ 3 | ↑ 3 | ↓ 3 | N | ↑ 3 | ↑ 3 | ↓ 4 | N | ↑ 3 | ↑ 3 | N | ↑ 3 | ↓ 3 | ↑ 3 | ||||||||
| Zátroch et al. (Hungary) [68] | Case report | 1 | ICU | Reference range as assessed by the manufacturer | N | N | N | N | N | N | N | N | N | N | N | ↑ | ↑ | N | ↑ | N | NP | Procoagulation, hypercoagulation and fibrinolysis shutdown | NA | Procoagulability: decreased CT. Hypercoagulability: Increased MCF |
| 1 | ICU | ↑ | N | ↑ | ↑ | N | N | ↓ | ↑ | ↑ | N | ↑ | ↑ | ↑ | N | ↑ | N | NP | ||||||
| 1 | ICU | ↑ | N | ↑ | ↑ | NP | ↑ | N | ↑ | ↑ | N | ↑ | ↑ | ↑ | N | ↑ | ↓ then normalization few days later | NP | ||||||
1p < 0.01 as compared with healthy subjects; 2 No difference as compared with ICU patients with LT ≤ 393 s (p > 0.05); 3 p < 0.01 as compared with ICU patients with LT ≤ 393 s; 4 p < 0.05 as compared with ICU patients with LT ≤ 393 s. Abbreviations: ICU: Intensive care unit (adults); RRT: Renal replacement therapy; tPA: tissue plasminogen activator; N: Result within the reference range; ↑: Result above the reference range; ↓: Result below the reference range; NP: Not provided; NA: Not assessed.