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IC50 values of individual enantiomers (R)-ricobendazole/(S)-ricobendazole and (R)-oxfendazole/(S)-oxfendazole on pancreatic, paraganglioma and colorectal cancer cell lines.
| Compound | IC50 (μM) | |||||
|---|---|---|---|---|---|---|
| Pancreatic Cancer | Paraganglioma | Colorectal Cancer | ||||
| AsPC-1 | BxPC-3 | PTJ64i | PTJ86i | HT-29 | SW480 | |
| (R)-ricobendazole | 9.09 | 13.6 | >20 | >20 | >20 | >20 |
| (S)-ricobendazole | >20 | >20 | >20 | >20 | >20 | >20 |
| (R)-oxfendazole | 1.18 | 1.82 | 10.02 | 12.41 | 10.02 | >20 |
| (S)-oxfendazole | >20 | >20 | >20 | >20 | >20 | >20 |
