Table 2.
Summary of the studies discussed in this review concerning the use of porphyrinoid PS for skin wound healing.
| Wound Type | Infection | PS | Log Reduction |
Improved Healing | Ref. | |
|---|---|---|---|---|---|---|
| Ex Vivo | Wound healing organ culture | Not infected | ALA | n.a. | YES | [68] |
| In vivo animal studies | Excisions | Not infected | ALA | n.a. | YES | [72] |
| AlPcCl-PEG | n.a. | YES | [55] | |||
| E. coli | pLCe6 | YES | inconclusive | [98] | ||
| Ce6-IL | YES | YES | [108] | |||
| TCPP-PB@MOF | YES | YES | [118] | |||
| TCPP-PCN224 | YES | YES | [119] | |||
| MOF-TCPP-Dopamine | YES | YES | [121] | |||
| PGA-TMPyP nanofibrous mat | YES | YES | [122] | |||
| AgNP/ZnPcCO2H fabric | YES | YES | [132] | |||
| P. aeruginosa | pL-Ce6 | YES | YES | [99] | ||
| pL–Cp6 | YES | NO | [110] | |||
| S. aureus | Ce6-IL | YES | YES | [108] | ||
| TCPP-PB@MOF | YES | YES | [118] | |||
| TCPP-PCN224 | YES | YES | [119] | |||
| MOF-TCPP-dopamine | YES | YES | [121] | |||
| PGA-TMPyP nanofibrous mat | YES | YES | [122] | |||
| MRSA; P. aeruginosa |
pL–Cp6 | n.d. | NO | [111] | ||
| TMPyP | YES | inconclusive | [117] | |||
| MRSA; E. coli; P. aeruginosa |
TDAHPP | YES | YES | [116] | ||
| MREC; MRAB |
ZnPc-(Lys)5 | YES | YES | [130] | ||
| MRSA | RLP068/Cl-cellulose gel | YES | YES | [126] | ||
| Abscesses | S. aureus | pLCe6 |
YES | inconclusive | [106] | |
| E. coli | YES | inconclusive | [106] | |||
| P. aeruginosa | YES | inconclusive | [106] | |||
| A. baumannii | YES | inconclusive | [100] | |||
| Burns | Not infected | MAL | n.a. | YES | [89] | |
| MRSA | PEI-Ce6 | YES | YES | [101] | ||
| RLP068/Cl | YES | YES | [127] | |||
| MDR S. aureus | Sinoporphyrin derivative | YES | YES | [112] | ||
| S. aureus | PTMPyP | YES | NO | [113] | ||
| Ulcers | MRSA | ALA | YES | YES | [79] | |
| Skin wounds (not specified) |
Not infected | Pheophorbide a | n.a. | YES | [97] | |
| Fotoditazin–Pluronic F127 | n.a. | YES | [107] | |||
| P. aeruginosa | ALA | YES | YES | [80,90] | ||
| S. aureus | HTCC-Ce6-Mg-EGCG NP | YES | YES | [109] | ||
| Incisions | Not infected | m-THPC-collagen scaffolds | n.a. | YES | [114] | |
| CASP | n.a. | YES | [121] | |||
| MPD-MA | n.a. | NO | [122] | |||
| In vivo human studies | Cutaneous Leishmaniasis lesions |
Leishmania major; Leishmania tropica |
ALA | n.d. | YES | [75] [76] |
| Leg Ulcer | MRSA | ALA | n.d. | YES | [78] | |
| P. aeruginosa | ALA | n.d. | YES | [69] | ||
| RLP068/Cl | YES | YES | [128] | |||
|
S. aureus; P. aeruginosa E. coli |
TPP | YES | YES | [115] | ||
| S. aureus | RLP068/Cl | YES | YES | [128] | ||
| Chronic Venous Ulcers |
E. faecalis | ALA | n.d. | YES | [81] | |
| MAL | n.d. | YES | [86] | |||
| S. aureus | ALA | n.d. | YES | [81] | ||
| MAL | n.d. | YES | [86] | |||
| Actinic Keratosis | Not infected | MAL | n.a. | YES | [82] | |
| Excisional Wounds | Not infected | MAL | n.a. | inconclusive | [67] |
n.a.—not applicable; n.d.—not determined.