Table 1.

Eligible animal studies reporting offspring outcomes related to CVD and kidney disease after resveratrol supplementation.

Species/Gender	Animal Models	Dose and Duration	Age at Evaluation	Offspring Outcomes	Ref.
Wistar ras/M & F	Maternal high-fat diet	Resveratrol (50 mg/L) in drinking water during gestation and lactation	3 weeks	Attenuated hyperglycemia, obesity and hyperlipidemia	[98]
Wistar rat/M & F	Maternal low protein diet	Resveratrol (20 mg/kg/day) via oral gavage during gestation	16 weeks	Attenuated obesity and insulin resistance	[99]
SD rat/M	Prenatal hypoxia and postnatal high-fat diet	Resveratrol (4 g/kg of diet) between 3 to 12 weeks of age	12 weeks	Improved cardiac tolerance to ischemia	[100]
SD rat/M	Prenatal hypoxia and postnatal high-fat diet	Resveratrol (4 g/kg of diet) between 3 to 12 weeks of age	12 weeks	Attenuated insulin resistance and hyperlipidemia	[101]
SD rat/M & F	Prenatal hypoxia and postnatal high-fat diet	Resveratrol (4 g/kg of diet) between 3 to 12 weeks of age	21 weeks	Improved cardiac dysfunction recovery after ischemia/reperfusion (I/R) injury	[102]
SD rat/M	Maternal plus post-weaning high-fructose diet	Resveratrol (50 mg/L) in drinking water from weaning to three months of age	12 weeks	Prevented hypertension	[103]
SD rat/M	Maternal chronic kidney disease	Resveratrol (50 mg/L) in drinking water during gestation and lactation	12 weeks	Prevented hypertension No effect on renal hypertrophy	[104]
SD rat/M	Maternal plus post-weaning high-fat diet	Resveratrol (50 mg/L) in drinking water during gestation and lactation	16 weeks	Prevented obesity, hypertension, and hyperlipidemia	[105]
SD rat/M	Maternal plus post-weaning high-fat diet	Resveratrol (50 mg/L) in drinking water during gestation and lactation	16 weeks	Attneuated hypertension	[106]
SD rat/M	Maternal L-NAME administration plus post-weaning high-fat diet	Resveratrol (50 mg/L) in drinking water during gestation and lactation	16 weeks	Prevented hypertension	[107]
SD rat/M	Maternal plus post-weaning high-fat diet	Resveratrol (50 mg/L) in drinking water during gestation and lactation	16 weeks	Prevented obesity	[108]
SD rat/M	Maternal TCDD and dexamethasone exposure	Resveratrol (0.05%) in drinking water during gestation and lactation	16 weeks	Prevented hypertension	[109]
SD rat/M	Maternal exposure to Bisphenol A and high-fat diet	Resveratrol (50 mg/L) in drinking water during gestation and lactation	16 weeks	Prevented hypertension	[110]
SD rat/M	Maternal plus post-weaning high-fat diet	0.5% resveratrol in drinking water between 2 to 4 months of age	16 weeks	Prevented hypertension	[111]
SHR/M & F	Genetic hypertension	Resveratrol (4 g/kg of diet) during gestation and lactation	20 weeks	Mitigated hypertension	[112]
C57BL/6 J mouse/M	Maternal plus post-weaning high-fat diet	0.2% w/w resveratrol in diet during gestation and lactation	14 weeks	Prevented obesity and hyperlipidemia	[113]

Studies tabulated according to species, animal models, and age at evaluation; SD rats = Sprague-Dawley rats; M = male; F = female; TCDD = 2,3,7,8-tetrachlorodibenzo-p-dioxin; L-NAME = N^G-nitro-L-arginine-methyl ester.