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. 2021 Feb 18;7(3):271–286. doi: 10.1002/cjp2.205

Figure 5.

Figure 5

ASPN and TNC expression in cribriform prostate cancer. (A) Representative images of dual ASPN (red) and TNC (blue) mRNA expression in stroma adjacent to benign prostate (n = 7), Gleason grade 3 prostate cancer (n = 4), Gleason grade 4 prostate cancer without cribriform morphology (n = 6), and Gleason grade 4 prostate cancer with cribriform morphology (n = 5) (×400 magnification). (B) The percentage of TNC + stromal cells adjacent to benign prostate, Gleason grade 3 prostate cancer, Gleason grade 4 prostate cancer without cribriform morphology, and Gleason grade 4 prostate cancer with cribriform morphology. (C) The relative expression of TNC in TNC + stromal cells. (D) The mean TNC H‐score. (E) The percent ASPN + TNC −, ASPN − TNC +, and ASPN + TNC + stromal cells adjacent to benign prostate, Gleason 3 prostate cancer, Gleason 4 without cribriform morphology prostate cancer, and Gleason 4 with cribriform morphology prostate cancer. Gene expression detected by RNAScope® and quantified with Halo® Software. Statistical analyses performed using one‐way analysis of variance with Tukey multiple comparisons. Graphs shown as mean ± SEM, *p ≤ 0.05, **p ≤ 0.01, ***p ≤ 0.001.