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. 2021 Apr 19;22(8):4229. doi: 10.3390/ijms22084229

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Ex vivo steroid production by intestinal tissue. (A) Changes in the levels of 11-dehydrocorticosterone (DCORT), corticosterone (CORT), progesterone (PROG) and 11-deoxycorticosterone (DOC) in tissue explants after 4 h incubation in tissue culture. (B) Effect of the anti-CD3 antibody, aminoglutethimide (AMG) and metyrapone (Met) on the level of corticosterone. (C) Effect of the anti-CD3 antibody, AMG and Met on the level of 11-dehydrocorticosterone. Specific pathogen-free (SPF) and germ-free (GF) mice were injected with saline (SHAM) or the anti-CD3 antibody and sacrificed 4 h later, and the intestinal fragments were cultured ex vivo in the presence or absence of AMG or Met for 4 h. * p < 0.05; ** p < 0.01; *** p < 0.001.