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. 2021 Apr 19;14(4):377. doi: 10.3390/ph14040377

Table 4.

Subset analysis for the detection of diarrhea induced by irinotecan (CPT-11) and 5-fluorouracil (5-FU) due to a drug–drug interaction.

Regimen Signal for CPT-11 Signal for 5-FU
N ROR (95% CI) N ROR (95% CI)
patients group using CPT-11 – – 3813 0.442
(0.398–0.491)
patients group using 5-FU 3813 2.091
(1.858–2.353)		 – –

“Signal for CPT-11” shows a signal for diarrhea in the CPT-11 patient group receiving 5-FU. “Signal for 5-FU” shows a signal for diarrhea in the 5-FU patient group receiving CPT-11.