Table 3.
Pathways significantly enriched by the downregulated genes in heat stress placentae (n = 5) compared with control placentae (n = 5).
| Pathway Database |
Term | Pathway ID | FDR (False Discovery Rate) |
Number of Genes Enriched |
|---|---|---|---|---|
| Reactome | Lysosomal oligosaccharide catabolism | R-SSC-8853383 | 0.042 | 2 |
| * Metabolism of carbohydrates | R-SSC-71387 | 0.000 | 10 | |
| Keratan sulfate biosynthesis | R-SSC-2022854 | 0.007 | 4 | |
| * Glycosaminoglycan metabolism | R-SSC-1630316 | 0.008 | 6 | |
| Sialic acid metabolism | R-SSC-4085001 | 0.009 | 4 | |
| * Synthesis of substrates in N-glycan biosynthesis | R-SSC-446219 | 0.043 | 4 | |
| O-linked glycosylation of mucins | R-SSC-913709 | 0.043 | 4 | |
| * O-linked glycosylation | R-SSC-5173105 | 0.044 | 5 | |
| Transport of inorganic cations/anions and amino acids/oligopeptides | R-SSC-425393 | 0.039 | 5 | |
| * SLC-mediated transmembrane transport | R-SSC-425407 | 0.008 | 9 | |
| KEGG | Metabolic pathways | KEGG:01100 | 0.001 | 31 |
| Lysosome | KEGG:04142 | 0.002 | 8 | |
| Glycosaminoglycan biosynthesis—keratan sulfate | KEGG:00533 | 0.027 | 3 | |
| Glycosphingolipid biosynthesis—ganglio series | KEGG:00604 | 0.034 | 3 |
* Where multiple pathway terms with loose hierarchy are significantly enriched, a broad ‘parent’ term and an associated ‘child’ term above are listed. KEGG: Kyoto Encyclopedia of Genes and Genomes.